Hyaluronidase is an enzyme (compounded by special pharmacies) that causes hydrolysis (breakdown) of hyaluronic acid. It is often referred to as a reversal agent for hyaluronic acid fillers. When the enzyme is injected it dissolves the synthetic hyaluronic acid filler, leaving your own intact. Liporase Hyaluronidase is made in Korea. It is used to dissolve hyaluronic acid based dermal fillers that have been placed incorrectly, excessively, or unevenly.
Liporase can be used to dissolve Dermal Fillers or to maximise the strength of lipodissolve injections. Liporase, also knowns as Hyaluronidase, is a tissue modifier indicated as an adjuvant in subcutaneous fluid administration for achieving hydration, to increase the dispersion and absorption of other injected drugs, and in subcutaneous urography for improving resorption of radiopaque agents.
Usge:
Usage
Use 1: Remove the filler. Injectable hyaluronidase dissolves hyaluronic acid in the dermal filler.
Use 2: In order to improve the effect of the fat-soluble injection, hyaluronidase can be added to the lipolysis injection.
Use 3: Hyaluronidase is often combined with a local anesthetic to increase the spread of local anesthetics.
contraindications of hyaluronidase for injection:
1. Hyaluronidase can not be injected within 48 hours after botoxin injection, because hyaluronidase can promote the serious spread of botox.
2. In order to avoid some acute and chronic diseases, there are still some medicines taken orally, especially those with allergic history.
3. The interval between hyaluronic acid injection and hyaluronic acid injection is usually safe within a week interval. If an emergency occurs, the interval is 72 hours. This is related to the absorption of drugs.
Important Info:
- Those with hypersensitivity to hyaluronidase or any other ingredient in the formulation is not allowed to use this product
- Discontinue recombinant (hyaluronidase human injection) if sensitization occurs.
- Hyaluronidase should not be used to enhance the absorption and dispersion of dopamine and/or alpha agonist drugs.
- Hyaluronidase should not be injected into or around an infected or acutely inflamed area because of the danger of spreading a localized infection.
- Hyaluronidase should not be used to reduce the swelling of bites or stings.
- Hyaluronidase should not be used for intravenous injections because the enzyme is rapidly inactivated.
- Furosemide, the benzodiazepines and phenytoin have been found to be incompatible with hyaluronidase.
- Anaphylactic-like reactions following retrobulbar block or intravenous injections have occurred, rarely.
- Hyaluronidase should not be applied directly to the cornea. It is not for topical use.
Efficacy and effect
Makes penetration of injection easy when subcutaneous injection, intramuscular injection or local anesthetics are injected under the skin to improves capability of absorbing excessive body fluid or blood in human organs.
! Before Use , dilute in 3-4 ml of 0.9% NaCl solution (saline)
Products containing hyaluronidase are intended for correcting unsuccessful results of beauty injections and for solving some other esthetic problems.
Main advantages
High quality and safety.
Provides a possibility to remove some part of filler after contour correction procedures.
Efficiently removes some scar formations without surgical interference.
Description and composition
It is released in the form of a lyophilized powder in 5 ml. vials. Product is available for purchase in packages - 10 pieces in each. The active component is a depolymerizing enzyme hyaluronidase, an activity of 1500 c.u.
Product purpose
Liporase inj. is used in aesthetic medicine.
Indications to using the product:
Overcorrection by fillers in contour plastics;
Granulomas (nodular formations);
Fibro-sclerotic form of cellulites.
Injections are made directly into the area of correction. Following the injection there starts the destruction of molecular compounds of hyaluronic acid. Shorter oligomers are injected naturally. The procedure result will be noticeable following 2 days.
Composition:
Depolymerizing enzyme hyaluronidase 1500 c.u. (activity is expressed in conditional units)
To Dissolve Filler:
- Draw 1ml of saline solution 0.9%.
- To dissolve more volume of filler, draw up 10ml of saline solution 0.9%.
- Inject the saline solution into the little bottle of Liporase until it's full.
- Mix it gently by rotating the Hyaluronidase bottle very gently.
- Draw back the mixed solution into the syringe.
- Inject it slowly into the filler where needs to be dissolved.
To maximise Lipodissolve injections. Same as above, but for fat dissolving injections, use 3ml of saline solution.